Clinical Characteristic of Acute Renal Failure in Patients with Severe Preeclampsia.
- Author:
Young Ok KIM
1
;
Yong Il KWON
;
Jae Hyoung CHO
;
Sun Ae YOON
;
Chul Woo YANG
;
Dong Jin KWON
;
Tae Chul PARK
;
Byung Kee BANG
Author Information
1. Department of Internal Medicine, Medical College, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Preeclampsia;
Acute renal failure;
Hypertension;
Pregnancy
- MeSH:
Acute Kidney Injury*;
Blood Pressure;
Hemolysis;
Humans;
Hypertension;
Hypoalbuminemia;
Incidence;
Liver;
Oliguria;
Placenta;
Postpartum Period;
Pre-Eclampsia*;
Pregnancy;
Pregnancy, Twin;
Pulmonary Edema;
Renal Dialysis;
Renal Insufficiency;
Retrospective Studies;
Risk Factors;
Thrombocytopenia
- From:Korean Journal of Nephrology
2000;19(3):429-436
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To evaluate the risk factors and clinical characteristics of acute renal failure(ARF) in patients with severe preeclampsia, we retrospectively investigated medical and obstetric histories, clinical and laboratory findings, maternal morbidity, and perinatal outcome between renal insufficiency and normal groups in patients with severe preeclampsia. Of the total 307 patients with severe preeclampsia, ARF occurred in 36 patients and its incidence was 11.7%. ARF developed before labor in 17 patients and postpartum in 19 patients. Oliguria occurred in 13 patients(36.1%) and 3 out of these patients required hemodialysis. Of the 31 patients who was observed for 3 months, renal function did not recover in 3 patients(9.7%). The systolic and diastolic blood pressures in renal insufficiency group(n=36) were higher than those in normal group(systolic:173+/-22 vs 164+/-19mmHg, p<0.02, diastolic:119+/-17 vs 108+/-14mmHg, p<0.01). In addition to degree of blood pressure, this study demonstrated that the risk factors of acute renal failure at admission were history of chronic hypertension, twin pregnancy, hypoalbuminemia, and thrombocytopenia. The incidences of maternal complications such as syndrome of hemolysis, elevated liver enzymes, and low platelets(HELLP syndrome), abruptio placenta, pulmonary edema and perinatal morbidity in renal insufficiency group were higher than those in normal group, respectively. In conclusion, acute renal failure in severe preeclampsia occur frequently in patients with history of chronic hypertension, twin pregnancy, severe hypertension, severe hypoalbuminemia, and thrombocytopenia.
