Preparation and Content Determination of Praziquantel Aquogel Suppository
- VernacularTitle:吡喹酮水凝胶栓剂的制备及含量测定
- Author:
Hong ZHANG
;
Xianling SHEN
- Publication Type:Journal Article
- Keywords:
Praziquantel;
Aquogel suppository;
Orthogonal design;
Poloxamer;
Content dertermination
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare praziquantel aquogel suppositories and to establish its assay method.METHOD:The optimal formula of the base was optimized by orthogonal experiment and the content of principal agent-praziquantel was determined by UV spectrophotometry.RESULTS:The optimized formula of the base was as follows,poloxamer P407∶P188(15%∶20%),sodium alginate 0.6%and ethyl alcohol 15%,the praziquantel aquogel suppositories prepared in this formula could be jellified under the body temperature with optimal viscosity.Good linear relationship occurred when the detection concentration of praziquantel was within a range of 0.2～10mg/ml(r=0.9 999),the average recovery of which was(102.44?0.69)%.CONCLUSION:The design of the formula is reasonable;the preparation process is reliable and the method for assaying is simple,fast and accurate.
