Relationship between Carotid Artery Intima-Media Thickness Measured by Ultrasonography and Apolipoprotein E and Angiotensin Converting Enzyme Gene Polymorphisms in Diabetic Nephropathy.
- Author:
Won KIM
1
;
Dal Sik KIM
;
Tae Sun PARK
;
Hong Sun BAEK
;
Sung Kyew KANG
;
Sung Kwang PARK
Author Information
1. Department of Internal Medicine, Chonbuk National University Medical School, Chonju, Korea. kwon@moak.chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Diabetic nephropathy;
Apo E poly-morphism;
Angiotensin converting enzyme polymorphisrn;
Carotid artery intima-media thickness
- MeSH:
Albuminuria;
Angiotensins*;
Apolipoproteins E;
Apolipoproteins*;
Carotid Arteries*;
Carotid Artery, Common;
Carotid Intima-Media Thickness;
Diabetic Nephropathies*;
Genotype;
Humans;
Logistic Models;
Male;
Peptidyl-Dipeptidase A*;
Polymerase Chain Reaction;
Ultrasonography*
- From:Korean Journal of Nephrology
2000;19(3):444-454
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: We evaluated the distribution of the polymorphisms of apolipoprotein E and angiotensin converting enzyme gene in patients with diabetic nephropathy and also evaluated possible association between the apolipoprotein E carriers and angioten-sin converting enzyme genotypes and intima-media thickness of the common carotid artery. METHODS: Study participants were 92 patients with diabetic nephropathy(50 men and 42 women). Hb(A1C), albuminuria, and lipid status were assessed by standard laboratory techniques ; the apolipoprotein E carriers were assessed by modified amplification refractory mutation system and the angioten-sin converting enzyme genotypes were assessed by polymerase chain reaction. The intima-media thickness was measured by high-resolution ultrasonography. RESULTS: The apolipoprotein E frequencies of patients were E2 8%, E3 76%, and E4 16%. The intima-media thickness varied by apo E groups. E2 group has less common carotid intima-media thickness than E3 and E4 groups(p<0.05). The angiotensin converting enzyme genotypes were distributed as follows ; 35% II, 49% ID, 16% DD. The intima-media thickness value did not differ among patients with various angiotensin converting enzyme genotypes. Multiple logistic regression analysis showed that age and apolipoprotein E genotypes were determinants for the intima-media thickness. CONCLUSION: Our results suggested that apolipoprotein E polymorphism is associated with carotid artery intima-media thickness in diabetic nephropathy. But, we could not find an association between carotid artery intima-media thickness and angiotensin converting enzyme gene polymorphism in diabetic nephropathy.
