Comparison of Dissolution Rates of Levofloxacin Tablets Produced by 4 Manufactures
- VernacularTitle:4厂家左氧氟沙星片溶出度考察
- Author:
Guangming HE
;
Nansong WANG
- Publication Type:Journal Article
- Keywords:
Levofloxacin tablets;
UV spectrophotometry;
Dissolution rate;
Comparison
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the dissolution rates of levofloxacin tablets produced in 4 domestic pharmaceutical manufacturers in order to provide the evidence for its clinical use.METHODS:UV spectrohpotmetry was used to determine the cumulative dissolution rates of these 4 kinds of levofloxacin tablets at different time points,the dissolution parameters of T50,Td,T80,and M were calculated by Weibull formula,then variance analysis was made.RESULTS:The dissolution rates of these 4 kinds of levofloxacin tablets all met the standards recorded in 2000 edition of China Pharmacopoeia,but significant differences were found in parameters of T50,Td,T80,and M(P
