Expression of 5-LOXmRNA and VEGFmRNA in pancreatic cancer and its clinical significance
- VernacularTitle:5-LOXmRNA和VEGFmRNA在胰腺癌中的表达及其临床意义
- Author:
Lihong LU
;
Bo ZHANG
;
Qingdong ZENG
;
Jun SHAO
;
Jincen YIN
- Publication Type:Journal Article
- Keywords:
RNA,Messenger/genet;
Pancreatic Neoplasms/blood;
Pancreatic Neoplasms/diag;
5-LOX/blood
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of 5-LOX in pancreatic cancer tissue and the relationship between 5-LOX expression and expression of VEGF.Methods The expression of 5-LOXmRNA,(VEGFmRNA) in 35 pancreatic cancer fresh tissue samples were detected by semi-quantitive reverse(transcriptase)-polymerase chain reaction method.Results Expression of 5-LOXmRNA,VEGFmRNA in(pancreatic) cancer tissue were 74.3%,60% respectively,and the expression was correlated to the with(clinical) stages of the tumor;also expression of VEGFmRNA was correlated to the differentiation of the tumor.Expression of 5-LOXmRNA and VEGFmRNA were synergetic in pancreatic cancer(P
