The expression of survivin gene and the relationship with proliferative activity in pancreatic adenocarcinoma
- VernacularTitle:Survivin在胰腺癌中的表达及其与胰腺癌增殖活性的关系
- Author:
Yuling WANG
;
Yuan LIU
;
Jianxun ZHANG
;
Chunlin GE
- Publication Type:Journal Article
- Keywords:
Pancreatic Neoplasms/genet;
Pancreatic/pathol;
Gene expression;
Immunonistochemistry
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Survivin and the relationship with proliferative activity in pancreatic carcinoma(PC).Methods The expression of SurvivinmRNA was investigated by reverse(transcriptase) polymerase chain reaction(RT-PCR) in 62 cases of PC samples,12 cases of chronic(pancreatitis)(CP) samples,and 10 cases of normal pancreatic tissue samples.Meanwhile,the expression of proliferative cell nuclear antigen(PCNA) was detected by immunohistochemical assay.Results The(expression) of Survivin gene was detected in a significantly greater proportion in PC(74.2%) than CP(0/12) and normal pancreatic tissue(0/10)(P
