Changes of Toll-like receptor 2 and 4 gene expression in lungs with acute injury induced by acute hemorrhagic necrotizing pancreatitis in rats
- VernacularTitle:Toll-样受体2,4mRNA在急性出血坏死性胰腺炎肺损伤中的表达变化
- Author:
Lei ZHANG
;
Heshui WU
;
Xin YU
;
Yan CHEN
;
Xingjun GUO
;
Lin WANG
;
Chunyou WANG
;
Jinghui ZHANG
;
Yuan TIAN
- Publication Type:Journal Article
- Keywords:
Acute Pancreatitis/compl;
Lung Diseares/etiol;
Lung/pathol;
Receptor,Toll;
Disease Models,Animal
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of Toll-like receptor 2 and 4 gene expression in lungs with acute injury induced by acute hemorrhagic necrotizing pancreatitis(AHNP) in rats.Methods Forty SD male rats were randomly divided into sham-operated group(n=10),and AHNP group(n=30).Of all the rats,the lungs were dissected for lung histological scores and bronchoalveolar lavages were harvested for lung injury index.TLR2,4mRNA expression in the lungs was measured by RT-PCR at different time points.(Results) TLR2,4mRNA could be detected in lungs with low values in sham-operated group;but they were markedly increased at 3 hours in AHNP group,peaking at 6~12 hours(P
