Expression of tissue factor in cerebral microvascular thrombosis in rats
- VernacularTitle:组织因子在大鼠脑微血管血栓形成中的表达
- Author:
Wei ZHOU
;
Yu HU
;
Huafang WANG
;
Lianjin LIU
;
Yadan WANG
;
Jine ZHENG
;
Wenning WEI
- Publication Type:Journal Article
- Keywords:
Photochemistry;
Intracranial thrombosis;
Endothelial cells;
Thromboplastin;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the expression of tissue factor (TF) in cerebral microvascular thrombosis and its dynamic changes in rats. METHODS: 50 female SD rats were randomized to control group, 2, 4, 6, and 24 hours after thrombosis groups, 10 rats in each group. The model of cerebral microvascular thrombosis was induced by photo-chemical method. ELISA and immunohistochemistry methods were used to observe the changes of TF contents in blood plasma and the expression of TF in cerebral microvascular in each group. RESULTS: Cerebral thrombosis was induced by photo-chemical method successfully. The TF content in plasma was obviously higher in 4 h and 6 h groups than that in control group (P
