Endothelin-1 and eNOS expression in pulmonary aterioles of patients with congenital heart diseases with pulmonary hypertension
- VernacularTitle:先天性心脏病伴肺动脉高压内皮素-1和内皮型一氧化氮合酶的表达
- Author:
Xia KONG
;
Rulian XIANG
;
Xingti HU
;
Baohui GAO
;
Qi CHEN
;
Zhouxi FANG
- Publication Type:Journal Article
- Keywords:
Endothelin-1;
Nitric oxide;
Nitric oxide synthase;
Heart disease, congenital;
Pulmonary hypertension
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To clarify the role of eNOS and ET-1 in development of pulmonary hypertension (PH) associated with congenital heart diseases. METHODS: 40 patients were randomly divided into three groups: severe or moderate PH group (group A, 12 cases), slight PH group (group B, 14 cases) and normal group (group C, 14 cases). ET-1 and eNOS were examined by using the technique of immunohistochemistry. RESULTS: ① Plasma ET-1 concentration was significantly higher in group A and B than that in group C (P
