Alteration of the redox status and its antioxidative capability in the tissue of malignant tumors
- VernacularTitle:恶性肿瘤组织的氧化还原态及其抗氧化能力的改变
- Author:
Chenheng WU
;
Shuren WANG
;
Yilun LIU
;
Xiaorong QIAO
;
Jiancheng ZHANG
;
Chenhao XIE
;
Yonggang LI
;
Zhanyong YE
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Oxidation-reduction;
Oxidoreductases
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the changes of the redox status and the antioxidative capability in the tissue of malignant tumors. METHODS: The carcinoma tissues collected from 42 patients with primary cancer in digestive tract (13 cases of esophageal cancer, 14 cases of gastric cancer and 15 cases of colorectal cancer),the corresponding paratumor mucosa tissues were taken as the control samples. The content of oxidized and reduced glutathion (GSSG and GSH), oxidized and reduced coenzyme II (NADP+ and NADPH) were measured, the GSH/GSSG, NADPH/NADP+ ratios, and the GSH/GSSG, NADPH/NADP+ redox potentials were calculated according to Nernst formula. RESULTS: The levels of GSH and NADPH in cancer tissues were significantly higher than those in corresponding paratumor tissues (P0.05). CONCLUSIONS: The significant increase in GSH and NADPH contents in cancer tissues indicates a notable enhancement of its antioxidative capability compared with the corresponding paratumor tissues. Based on this changes, the redox potential in the cancer tissues has only slightly reductive shift, which may suggest an apparent oxidative stress existed in the cancer tissues.
