B allele in I?1 hs1,2 VNTR region is associated with IgA nephropathy
- VernacularTitle:I?1基因hs1,2区B等位基因与IgA肾病的易感性相关
- Author:
Hongbiao GU
;
Youji LI
;
Yong DU
;
Weijun HUANG
;
Caixia LI
;
Suqin CHEN
;
Yiming WANG
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis, IGA;
Immunoglobulin A;
Enhancer elements (genetics);
Variable numbers of tandem repeats;
Polymorphism (genetics);
Transmission/Disequilibrium Test
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the relationships between I?1 hs1,2 VNTR polymorphism and IgA nephropathy. METHODS: Four hundred and ninteen patients with IgA nephropathy and their first-degree relatives were recruited. Two hundred and one sex and age-matched normal Chinese Han volunteers were also recruited as controls. After extracting genomic DNA, the VNTR genotypes of I?1 hs1,2 region were determined by PCR and electrophoresis, and the results were analyzed by transmission disequilibrium test (TDT) and haplotype relative risk (HRR) in the families, and Chi-Square test in the case-control analysis. RESULTS: ① TDT analyses showed that B allele of the I?1 hs1,2 VNTR region was significantly more transmitted from heterozygous parents to patients than expected (101 Trios, ?2=6.818, P
