Changes in cerebral vaso- active substances in patients undergoing intracranial aneurysm clipping under propofol-fentanyl anesthesia
- VernacularTitle:异丙酚-芬太尼麻醉下颅内动脉瘤夹闭术中患者收缩和舒张脑血管物质的变化
- Author:
Fang WO
;
Shuzhen ZHANG
;
Enzhen WANG
- Publication Type:Journal Article
- Keywords:
Propofol;
Fentanyl;
Angiotensin Ⅱ;
Endothelins;
Calcitonin gene-related peptide;
Cerebral aneurysm
- From:
Chinese Journal of Anesthesiology
1997;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
90 bpm and nicardipine 10?g?kg-1 when MAP increased by 20% of the baseline value. Radial artery was cannulated for continuous BP monitoring and blood sampling. MAP, ECG, HR, SpO2 , PET CO2 and body temperature were continuously monitored during anesthesia. Blood samples were taken before induction of anesthesia (T1), when dura was cut (T2), when aneurysm was clipped (T3 ) and 30 min after clipping (T4 ) for determination of plasma concentrations of AT- Ⅱ , ET and CGRP by radioimmuno-assay.Results Plasma concentration of AT- Ⅱ and HR did not change significantly through out the study. Plasma CGRP concentration and MAP decreased significantly during operation at T2-4 as compared to the baseline values (T1 ) . Plasma ET concentration increased significantly at clipping (T3 ) as compared to that at T2. Conclusion The action of vaso-constrictors (AT- Ⅱ , ET) predominates over that of vaso-dilator during operation. It is important to prevent acute cerebral vasospasm during intracranial aneurysm clipping.
