Expressions of COX-2 and VEGF in non-small cell lung cancer and the relationships between them and tumor angiogenesis
- VernacularTitle:非小细胞肺癌组织中COX-2和VEGF的表达及其与肿瘤血管生成的研究
- Author:
Lanyan ZHU
;
Ping CHEN
;
Yunsheng JIANG
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Cyclooxygenase-2;
Vascular endothelial growth factor;
Immunohistochemical staining
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of Cycloxygenase-2(COX-2),vascular endothelial growth factor(VEGF) in non-small cell lung cancer(NSCLC) to explore the relationships between them and the tumor biological characteristics,tumor angiogenesis in NSCLC.Methods The expressions of COX-2,VEGF and the microvessel density(MVD) were detected by immunohistochemical staining.Results The positive rates of COX-2 and VEGF expression in NSCLC tissue were 55.5% and 66.7% respectively,with significantly higher than those of normal lung tissue(all P
