Expression of vascular endothelial growth factor-C and its receptor Flt-4 in papillary thyroid carcinoma
- VernacularTitle:血管内皮生长因子-C及其受体Flt-4在甲状腺乳头状癌中的表达
- Author:
Hongbo ZHANG
;
Qiyou WEI
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinoma;
Vascular endothelial growth factor-C;
Vascular endothelial growth factor receptor-3;
Neoplasm metastasis
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role and significance of the expressions of vascular endothelial growth factor-C(VEGF-C) and its receptors Flt-4 in metastasis of papillary thyroid carcinoma(PTC).Methods The expression levels of VEGF-C and Flt-4 were detected in 87 cases of PTC with SABC immunohistochemical method.Results Among 87 cases of PTC,the positive rates of VEGF-C and Flt-4 were 89.66%(78/87) and 81.61%(71/87),respectively.There was positive correlation between the expression of VEGF-C and Flt-4.The expression of VEGF-C in lymph node metastasis group was significantly higher than that of no lymph node metastasis group(P
