Study on stained elastic fibers and expression of collagen type Ⅳ,CD44v6 with metastasis of lung adenocarcinoma
- VernacularTitle:弹力纤维及Ⅳ型胶原和CD44v6表达与肺腺癌转移的研究
- Author:
Zhidong WANG
;
Zijun ZHANG
;
Chengfang WANG
- Publication Type:Journal Article
- Keywords:
Adenocarcinoma;
Pulmonary;
Elastic fibers;
Collagen type Ⅳ;
CD44v6;
Metastasis
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of elastic fibers,Collagen type Ⅳ and CD44v6 in the metastasis of the pulmonary adenocarcinoma.Methods In paraffin-embedded specimens from 56 cases of pulmonary adenocarcinoma,the elastic fibers were stained with histochemical method and the expressions of collagen type Ⅳ and CD44v6 were detected with immunohistochemical method.Results The positive expression rates of elastic fibers,collagen type Ⅳ and CD44v6 were 11.5%(3/26),11.5%(3/26) and 80.8%(21/26)in the group with lymph node metastasis,and were 69.0%(20/29),55.2%(16/29) and 24.1%(7/29) in the group without lymph node metastasis,respectively.The expression of elastic fibers,collagen type Ⅳ and CD44v6 were significant difference in the two groups with and without lymph node metastasis(P=0.000).There was statistically significant correlation among elastic fibers,collagen type Ⅳ,CD44v6 and lymph node metastasis(all P
