The value of liver biopsy for pathological diagnosis in liver transplant patients
- VernacularTitle:肝脏穿刺活检在诊断移植肝病理改变中的价值
- Author:
Yanqing WANG
;
Qiang XIA
;
Jianjun ZHANG
;
Jianshan ZHU
;
Xiaosong CHEN
;
Ming ZHANG
;
Yi LUO
;
Conghuan SHEN
;
Tianyu XING
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Biopsy,needle;
Diagnostic pathology
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate liver biopsy for the diagnosis in liver transplant patients with suspected acute rejection. Methods From Oct. 2004 to Apr. 2005, liver biopsies were performed 53 times in 39 transplant cases. Results Based on Banff schema for grading liver allograft rejection, laboratory abnormalities and result of treatment, acute rejection was diagnosed on 16 episodes, preservation injury in 12, bile duct strictures in 9, drug-induced injury in 11, chronic rejection in 3 and acute hepatic failure in 2. Conclusions Hepatocyte ballooning with necrosis features preservation injury. Drug-induced injury commonly has a combination of hepatocyte denaturalization with mild portal inflammation. Histologic features of early bile duct strictures in liver biopsy show prominent bile ductular proliferation and the canalicular cholestasis with mild hepatocyte damage which help to exclude acute rejection.
