The effects of urinary trypsin inhibitor on patients undergoing liver resection of different extents:a prospective clinical study
- VernacularTitle:乌司他丁对不同范围肝脏切除影响的前瞻性临床研究
- Author:
Xin LU
;
Yilei MAO
;
Xinting SANG
;
Zhiying YANG
;
Shouxian ZHONG
;
Jiefu HUANG
- Publication Type:Journal Article
- Keywords:
Trypsin inhibitors;
Hepatectomy;
Liver function
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Ulinastatin, a urinary trypsin inhibitor on the outcome of patients undergoing liver resection. Methods In this prospective, randomized, and controlled clinical study, 42 patients undergoing hepatectomy were randomly divided into treatment group and control group. In treatment group Ulinastatin was given on the day of surgery and the three consecutive days. Blood was tested for biochemistry. ResultsSerum ALT and AST levels in treatment group were significantly lower than those in control group 12 hours post-operation, especially in patients undergoing multisegmentectomy. Difference became insignificant at the time point of 60 hours post-operation. Administration of Ulinastatin resulted in faster decrease of serum bilirubin level in patients undergoing small volume hepatectomy, and no effect on coagulative function was observed. Conclusions The protective effects of urinary trypsin inhibitor exist mainly in early stage of major liver resection.
