The Effects of Fosinopril on the Structural Changes of Mesenteric Resistance Vessels in Sinoaortic - den- ervated Rats
- VernacularTitle:福辛普利对去窦弓神经大鼠肠系膜阻力血管结构改变的影响
- Author:
Xia TAO
- Publication Type:Journal Article
- Keywords:
Fosinopril;
Sinoaortic-denervation;
Rats;
Angiotensin - converting enzyme inhibitor;
Resistance vessels
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the reverse effect of angiotensin - converting enzyme (ACE) inhibitor - fosinopril on the structural changes of mesenteric resistance vessels in sinoaortic - denervated (SAD) rats. METHODS; The rats were randomly divided into SAD group, fosinopril treatment group after SAD operations; besides, another sham operation control group was established. The rats were put to death after medication and (or) feeding for 16 weeks. The histopathological changes of the second order branch of mesenteric artery taken from the rats were observed by light microscope and computer - assisted image analysis. RESULTS: The wall thickness, the ratio of wall thickness to internal diameter, the wall area, the ratio of numbers of smooth muscle cells to field of view of the mesenteric resistance vessels diminished significantly in the fosinopril treatment group; however, no significant change was noted for the relative area of the smooth muscle in this group vs. the SAD group. CONCLUSION: Fosinopril can efficiently inhibit the structural changes of mesenteric resistance vessels in SAD rats.
