Pentoxifylline Modified Release Capsules' Preparation and Its in Vitro Drug Release Characteristics
- VernacularTitle:己酮可可碱缓释胶囊的研制及其体外释药特性考察
- Author:
Jinping WANG
- Publication Type:Journal Article
- Keywords:
Pentoxifylline;
Modified release capsule;
Orthogonal design;
Preparation;
In vitro drug release
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare pentoxifylline(PTX) modified release capsule and to investigate its in vitro drug release characteristics. METHODS: The orthogonal design was adopted to optimize the formula and the preparation technics; and the contents of PTX were determined by UV - spectrophotometry. RESULTS: The optimized formula and preparation technics were as follows: PTX 200mg, hydroxy propyl methylcellulose 90mg, stearic acid 60mg, octadecyl alcohol 50mg, flu-idization for 25min at 80℃;PTX assumed linear relationship with absorbability at the range of 1.0-10.0?g /ml(r = 0.9 995), the average recovery was 101.24% , RSD = 1.27% (n = 6) . CONCLUSION: The optimized technics is simple and easy to handle; PTX modified release capsules prepared in the technics were of good stability and which have an obvious in vitro slow release property.
