QTc Prolongation after Ventricular Septal Defect Repair in Infants.
10.4070/kcj.2013.43.12.825
- Author:
Chang Woo HAN
1
;
Saet Byul WOO
;
Jae Young CHOI
;
Jo Won JUNG
;
Yong Hwan PARK
;
Han Ki PARK
;
Hong Ju SHIN
;
Nam Kyun KIM
Author Information
1. Division of Pediatric Cardiology, Department of Pediatrics, Congenital Heart Disease Center, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. pednk@yuhs.ac
- Publication Type:Original Article
- Keywords:
Ventricular septal defect;
Electrocardiography;
Infant
- MeSH:
Arrhythmias, Cardiac;
Atrial Premature Complexes;
Electrocardiography;
Heart Septal Defects, Ventricular*;
Humans;
Incidence;
Infant*;
Intensive Care Units;
Intubation;
Length of Stay;
Linear Models;
Retrospective Studies;
Tachycardia;
Tachycardia, Ectopic Junctional;
Thoracic Surgery;
Ventricular Premature Complexes
- From:Korean Circulation Journal
2013;43(12):825-829
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Prolonging of the corrected QT interval (QTc) has been reported after cardiac surgery in some studies. However, there have not been many studies on infant open cardiac surgery for ventricular septal defect (VSD) repair. This study was performed to define the changes in QTc and to find related post-surgery factors in this patient group. SUBJECTS AND METHODS: From 2008 to 2012, 154 infants underwent VSD repair at the Severance Cardiovascular Hospital. This study includes 105 of these cases. QTc was measured in these patients retrospectively. Demographic data and peri-procedural data, such as Aristotle score, cross-clamp time and bypass time, were analyzed. The exclusion criteria included multiple and small VSDs that underwent direct closure. RESULTS: Mean post-operative QTc was increased compared to the pre-operative measurements (from 413.6+/-2.3 to 444.9+/-2.5, p<0.001). In multiple linear regression, the comprehensive Aristotle score was associated with increasing QTc (p=0.047). The incidence of transient arrhythmia, such as atrial tachycardia, junctional ectopic tachycardia, premature atrial contraction, or premature ventricular contraction, was associated with QTc prolongation (p=0.005). Prolonged QTc was also associated with cross-clamp time (p=0.008) and low weight (p=0.042). Total length of stay at the intensive care unit and intubation time after surgery were not associated with QTc prolongation. CONCLUSION: Prolonged QTc could be seen after VSD repair in infants. This phenomenon was associated with peri-procedural factors such as the Aristotle score and cross-clamp time. Patients with QTc prolongation after cardiac surgery had an increased tendency towards arrhythmogenicity in the post-operative period.
