Platelet-activating Factor Acetylhydrolase Gene Mutation and Psoriasis
- VernacularTitle:银屑病患者血小板活化因子乙酰水解酶基因突变的研究
- Author:
Tianbao XIA
;
Xinling BI
;
Jun GU
;
Mingyong MIAO
;
Suling LI
;
Jie WANG
;
Qingju SUN
;
Jun YU
- Publication Type:Journal Article
- Keywords:
Psoriasis;
1-Alkyl-2-acetylglycerophosphocholine esterase;
Mutation
- From:
Chinese Journal of Dermatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between a mutation in the platelet-activating factor (PAF) acetylhydrolase gene (Arg92→His) and psoriasis. Methods Genomic DNA was analyzed in 47 patients with psoriasis and 52 healthy controls via polymerase chain reaction and restriction fragment length polymorphism. Results The frequency of the mutation in the PAF acetylhydrolase gene (Arg92→His) was significantly higher in patients with psoriasis than that in the controls (P
