Effects of the Acute Sodium Salicylate Injection on the Distortion Product Otoacoustic Emissions of Awake Guinea Pigs
- VernacularTitle:水杨酸钠急性注射对清醒豚鼠畸变产物耳声发射的影响
- Author:
Yanyun LUO
;
Zhiwu HUANG
;
Zhanyuan WU
- Publication Type:Journal Article
- Keywords:
Distortion product otoacoustic emission;
Sodium salicylate;
Out hair all;
Ototoxicity
- From:
Journal of Audiology and Speech Pathology
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change and the characteristics of distortion product otoacoustic emissions (DPOAE) of awake guinea pigs with the acute injection of sodium salicylate, and to investigate the ototoxicity of sodium salicylate to OHC. Methods With CELESTA 503 otoacoustic emission analyzer, DPOAE including DP-gram and DP-I/O function of awake guinea pigs were recorded.DPOAE were measared before and 2,4,8 h after acute injection of sodium salicylate or saline respectively. The data were analysed with SPSS 10.0.Results Acute sodium salicylate injection mainly caused the DPOAE amplitude and the I/O slope to reversibly decrease and increase respectively. The changes were largest 2 h after injection, and almost returned to normal level 8 h after injection. The differences between certain outcomes of DPOAE after and before injection were significant (P
