Expressions and clinical significance of CD83 and S100 on gastric cancer infiltrating dendritic cells
- VernacularTitle:胃癌浸润性树突状细胞CD83和S100的表达及其临床意义
- Author:
Xiao LEI
;
Peiwu YU
;
Yan SHI
;
Bo TANG
;
Yun RAO
;
Miao WU
;
Lixin ZHOU
- Publication Type:Journal Article
- Keywords:
Stomach Neoplasms/pathol;
Neoplasms Invasiveness;
CD83;
S100
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of tumor infiltrating dendritic cells(TIDCs) within gastric tumor tissues.Methods Immunohistochemistry(IHC),in-situ hybridization(ISH) and flow cytometry were applied to detect the expression of S100,CD83 mRNA and CD83 on DCs in 45 gastric adenocarcinoma tissues.The co-relationship of the S100 and CD83 expression with clinical(pathological) features was analyzed.Results IHC showed that S100 expression was unevenly distributed(within) 42 cancer tissue and CD83 was only expressed in tumor-adjacent tissue and normal tissue.ISH showed that CD83 mRNA was limitedly expressed within 7 samples.S100 expression had no significant(correlation) with clinical pathological features,while CD83 reversely correlated with TNM stages.Detected by flow cytometry,CD83 was expressed in low level in all 45 gastric cancer tissues and negative correlations were found with lymph node metastasis and TNM stages of gastric cancer(r=-0.879,P
