Cyclical Variations of Blood Concentration of Phenytoin and Its Pharmacokinetics in Menstrual Epilepsy
- VernacularTitle:经期性癫痫苯妥英血药浓度及药动学的周期性变化
- Author:
Songqing PAN
;
Zuneng LU
;
Danhong WU
;
Shunde LUO
;
Xianzhou ZHANG
- Publication Type:Journal Article
- Keywords:
Menstrual epilepsy;
Phenytoin;
Menstrual period;
Ovulation period;
HPLC;
Blood concentration
- From:
China Pharmacy
2005;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the changes of serum phenytoin levels and its pharmacokinetics in menstrual epilepsy.METHODS:9cases of menstrual epilepsy patients who were treated with phenytoin were collected,whose blood concentra?tions of phenytoin in menstrual period and ovulation period were respectively determined by HPLC,pharmacokinetics study was performed in three of them.RESULTS:The mean serum phenytoin levels in menstrual period and ovulation period were(9.25?2.71)?g/ml and(13.33?3.22)?g/ml,respectively(P
