Effect of oxymatrine on sodium channel in isolated ventricular myocytes in guinea pig
- VernacularTitle:氧化苦参碱对豚鼠心室肌细胞膜钠通道的影响
- Author:
Aidong ZHANG
;
Zicheng LI
;
Ningning ZHUANG
- Publication Type:Journal Article
- Keywords:
Oxymatrine;
Patch - clamp techniques;
Sodium channels;
Myocardium
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of oxymatrine on sodium channel in isolated cardiomyocytes of guinea pig. METHODS: Single ventricular myocytes of guinea pigs were obtained by enzymatic dissociation. The whole - cell patch clamp recording technique was used to record the change of sodium current by different dosage of oxymatrine from 1 to 1 000 ?mol?L-1 . RESULTS: Oxymatrine decreased sodium current in a dose - dependent manner. Oxymatrine (100 ?mol?L-1) decreased the current density by 40% (P
