Allicin inhibits hippocampal neuronal apoptosis induced by global cerebral ischemia-reperfusion
- VernacularTitle:大蒜素抑制脑缺血-再灌注诱导的海马神经元凋亡及其机制初探
- Author:
Lili REN
;
Qingjun LI
;
Wenbin LI
;
Xinhua GUO
;
Lingyun LIU
;
Honggang ZHAO
- Publication Type:Journal Article
- Keywords:
Allicin;
Brain ischemia;
Reperfusion injury;
Apoptosis;
Hippocampus
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of allicin on hippocampal neuronal apoptosis induced by global cerebral ischemia - reperfusion and its mechanisms. METHODS: Wistar rats were subjected to 15 min global cerebral ischemia followed by 72 h reperfusion. Flow cytometry (FCM) was used to evaluate the rate of hippocampal neuronal apoptosis and colorimetric method was used for the measurement of nitric oxide (NO) , malondialdehyde (MDA) contents and superoxide dismutase (SOD) activity in hippocampal tissue. RESULTS: Neuronal apoptotic rate, nitric oxide and malondialdehyde contents in hippocampal tissues of rats in I - R group were significantly higher than those in sham group. However, superoxide dismutase activity in hippocampal tissues of rats in I - R group was obviously lower than that in sham group. Allicin pretreatment inhibited the above changes in a dose-dependent manner. CONCLUSION: Allicin hihibits hippocampal neuronal apoptosis induced by global ischemia-reperfusion insult through anti - oxidation. The anti - oxidation action of allicin may be one of the mechanisms of inhibitory effects on hippocampal neuronal apoptosis.
