The Preventive Effect of Systemic Treatment with Interferon-alpha2B for Infertility of Mumps Orchitis.
- Author:
Ja Hyeon KU
;
Yong Soon YIM
;
Chang Ho LEE
;
Young Ho KIM
;
Yun Seob SONG
;
Youn Soo JEON
;
Min Eui KIM
;
Nam Kyu LEE
;
Young Ho PARK
- Publication Type:Original Article ; Randomized Controlled Trial
- MeSH:
Atrophy;
Follow-Up Studies;
Humans;
Infertility*;
Male;
Mumps virus;
Mumps*;
Orchitis*;
Semen Analysis;
Sperm Count;
Testis
- From:Korean Journal of Fertility and Sterility
1999;26(1):111-116
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Postpubertal mumps may result in ochitis and permanent testicular atrophy may develop following infection. This present study was initiated to evaluate the preventive effect of interferon-alpha2B on infertilty after mumps orchitis. There were 21 patients with mumps orchitis between May 1990 and June 1997. Patients were randomly distributed into 2 groups: group 1 patients (n=13) maintained therapy with interferon-alpha2B (3x10(6) IU per day) and group 2 were managed by conservatively. All of the patients were evaluated with testis size measurement, mumps virus titer, hormone level, and if possible semen analysis. For group 1 patients symptoms disappeared within 2 to 3 days and the volume of testis returned to normal within 11 days and testis atrophy was not observed in all patients in follow up. But asthenospermia was continued in 4 patients (unilateral 2, bilateral 2). For group 2 patients symptoms disappeared within 5 to 6 days and the volume of testis returned to normal within 10 days and testis atrophy was observed in 3 patients (unilateral 2, bilateral 1) in floow up. Asthenospermia was continued in 4 patients (unilateral 2, bilateral 2). Sperm count and morphology were recovered all the recover in group 1, 4 patients had persistent reduced sperm count and morphology in group 2, respectively. These observations suggest that systemic interferon-alpha2B treatment is highly effective in preventing infertility as well as testicular atrophy after mumps orchitis.
