Function of I?B kinase links inflammation and cancer
- VernacularTitle:IKK?在炎症与肿瘤中的作用
- Author:
Chenli LIN
;
Xueyun ZHONG
;
Yanfang QIN
- Publication Type:Journal Article
- Keywords:
I?B kinase;
NF- kappa B;
Inflammation;
Neoplasms
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
It has long been acknowledged that there is a link between inflammation and cancer, but its molecular mechanism remains unclear. A key player in inflammation is nuclear transcription factor NF-?B, that activity is triggered in response to infectious agents and proinflammatory cytokines via the I?B kinase. In parenchyma cells, inflammation through I?B kinase/NF-?B pathway suppresses apoptosis, accelerates cell cycle, then promote tumorigenesis. In mesenchyma cells inflammation through I?B kinase/NF-?B pathway produces cytokines and chemokines that may serve as tumor growth factors. To sum up, I?B kinase/NF -?B pathway represents a critical molecular link between inflammation and cancer.
