Association of Angiotensin I-converting enzyme Gene Polymorphisms with the Carotid Intima-media Thickness in Type 2 Diabetes Mellitus
- VernacularTitle:ACE基因多态性与T2DM患者股动脉内中膜厚度的关系
- Author:
Yuhua LIU
;
Zhiguang ZHOU
;
Xiaoyan CHEN
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Gene polymorphism;
Angiotensin I-converting enzyme gene;
Femoral artery
- From:
Journal of Chinese Physician
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between angiotensin I-converting enzyme(ACE)inserting/defaulting(I/D) gene polymorphisms and the femoral artery intima-media thickness(FA-IMT) in patients with type 2 diabetes mellitus(T2DM).Methods The polymorphisms of ACE(I/D) was determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method and the FA-IMT was assessed using non-invasive high resolution B-mode ultrasonography in 303 patients with T2DM in Hunan province.Results The frequency of I allele of ACE gene polymorphisms was higher in T2DM than that in healthy controls,but frequency of D allele was lower in T2DM than that in healthy controls(P
