The Influence of Superantigen Staphylococcal Enterotoxin B on the Proliferation of TILs from Rectum Adenocacinoma
- VernacularTitle:超抗原SEB对直肠腺癌TIL扩增的研究
- Author:
Fengfeng XU
;
Min TAN
;
Yuyang ZHEN
- Publication Type:Journal Article
- Keywords:
Staphylococcal enterotoxin B;
Tumor infiltrating lymphocyte;
Rectum adenocacinoma;
Cytokine
- From:
Journal of Chinese Physician
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of staphylococcal enterotoxin B(SEB) on the proliferation of tumor infiltrating lymphocytes(TILs) from rectum adenocacinoma.Methods The TILs from patients with rectum adenocacinoma were stimulated with SEB and interleukin 2(IL-2) respectively,and then the proliferation of TILs,the secretion of IL-2 and tumor necrosis factor-?(TNF-?) were determined.Results SEB presented profound stimulating effect on the TILs from rectum adenocarcinoma both the proliferation of TILs and the secretion of cytokines.Compared with the IL-2,SEB stimulated TILs more quickly,and SEB acted more effectively in the early stage but weakly in the late stage.Conclution SEB was an effective TIL stimulator.
