The iNOS Expression and Apoptosis in Psoriasis Vulgaris, Lichen Planus and Bowen's Disease.
- Author:
Yoon Jeong CHOI
;
Hae Young CHOI
;
Ki Bum MYUNG
- Publication Type:Original Article
- Keywords:
Apoptosis;
iNOS;
TUNEL
- MeSH:
Apoptosis*;
Bowen's Disease*;
Endothelium-Dependent Relaxing Factors;
Epidermis;
In Situ Nick-End Labeling;
Lichen Planus*;
Lichens*;
Neurotransmitter Agents;
Nitric Oxide;
Psoriasis*;
Skin
- From:Korean Journal of Dermatology
1999;37(4):449-458
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Nitric oxide(NO), a multifunctional mediator, is known as a endothelium-derived relaxing factor, a neurotransmitter, and a killer molecule formed by activated immune cells and participates in tissue destruction via apoptosis. In the skin, an increase in apoptotic cells has been desribed in the epidermis in various lichenoid diseases, in response, to ultraviolet radiation, and in neoplasia. OBJECTIVE: The purpose of this study is to investigate whether a positive correlation occurs between iNOS(inducible nitric oxide synthase) expression and apoptosis index in psoriasis vulgaris(PV), lichen planus(LP), and Bowen's disease(BD). METHODS: TUNEL staining and immunohistochemical staining with anti-iNOS antibody were done in paraffin-embedded tissue sections of 4 cases of PV, 4 cases of LP, and 2 cases of BD.
