Relationship between the Expressions of Intercellular Adhesion Molecule 1,Heat Shock Protein 70 and Acute Rejection after Pancreas Allotransplantation in Miniature Swine
- VernacularTitle:细胞间黏附分子-1及热休克蛋白70与猪同种异体胰腺移植排斥反应的关系
- Author:
Jing LI
;
Ping LIANG
;
Yong YANG
- Publication Type:Journal Article
- Keywords:
Pancreas transplantation;
Intercellular adhesion molecule 1;
Heat shock protein;
Rejection
- From:
Journal of Chinese Physician
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationships between the expressions of intercellular adhesion molecule 1(ICAM-1),heat shock protein 70(HSP70) and acute rejection after pancreas allotransplantation in miniature swine.Methods Ultrasound guided biopsies of the pancreas and histopathologic examination were performed after the miniature swine models of pancreas allotransplantation were established.According to the histological change,the samples were divided into group Ⅰ(no rejection),group Ⅱ(mild acute rejection),group Ⅲ(moderate acute rejection)and group Ⅳ(serious acute rejection).The expressions of ICAM-1 and HSP70 were analyzed with immunohistochemistry and imaging.Results The expressions of ICAM-1 and HSP70 were increased when acute rejection occurred after pancreas allotransplantation in miniature swine.The levels of ICAM-1 and HSP70 were sequentially high when acute rejection was serious.Conclusion ICAM-1 and HSP70 were involved in pancreas allograft rejection and useful for early diagnosis of acute rejection after pancreas transplantation.
