VEGF delivering-fibrin glue accelerates arterial endothelialization
- VernacularTitle:纤维蛋白胶释放VEGF加速损伤动脉血管内皮化的实验研究
- Author:
Jiefang BIAN
;
Zhong MA
;
Qing YAO
;
Juliang ZHANG
;
Jianghao CHEN
;
Ting WANG
;
Xiling WANG
- Publication Type:Journal Article
- Keywords:
Endothelial growth factors;
Fibrin;
Angioplasty;
Drug delivery systems;
Intimal hyperplasia
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of vascular endothelial growth factor (VEGF) containing fibrin glue(FG) on re-endotheliazation, cell proliferation and intimal hyperplasia in a canine model of carotid artery endothelium injury. MethodsThe effect of FG/VEGF/heparin versus FG alone treatment was evaluated at the time point of 10, 30, and 90 days by measuring the intima/media (I/M) ratio and cell proliferation by BrdU incorporation using immunohistochemistry. EC coverage was determined by SEM. ResultsCompared with normal saline control, FG/VEGF/heparin treatment significantly increased EC coverage at day 10 and at day 30 (P
