The Study of Tenascin Expression in Vitiligo.
- Author:
Jong Seong AHN
;
Kyung Chan PARK
;
Young Gull KIM
;
Kwang Hyun CHO
;
Jung Wook SEO
;
Duk Kyu CHUN
- Publication Type:Original Article
- Keywords:
Tenascin;
vitiligo
- MeSH:
Cell Adhesion;
Extracellular Matrix;
Glycoproteins;
Humans;
Melanocytes;
Skin;
Tenascin*;
Vitiligo*
- From:Korean Journal of Dermatology
1999;37(4):495-499
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Defective adhesion and migration of melanocyte may be involved in pathogenesis of vitiligo. Tenascin, a glycoprotein of the extracellular matrix, has a role in cell adhesion and migration. It has been reported that abundant expression of tenascin in vitiligo lesion may inhibit melanocyte adhesion and migration. OBJECTIVE: To investigate the tenascin expression in vitiligo skin lesions and to compare with clinical findings. METHODS: We studied 9 patients with vitiligo. The expressions of tenascin were studied by immunahistochemieal techniques.
