Optimization of Base Material Compositions of Compound Ciprofloxacin Gel by Orthogonal Test and Its Preparation Technology
- VernacularTitle:正交试验优选复方环丙沙星凝胶基质组成及制备工艺
- Author:
Mingpei LIU
;
Fang LI
;
Haisheng JIAO
;
Heng ZHU
- Publication Type:Journal Article
- Keywords:
Orthogonal test;
Ciprofloxacin hydrochloride;
Gel;
Carbomer-940
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize base material compositions and preparation technology for compound ciprofloxacin gel.METHODS:4factors,ciprofloxacin,carbomer-940,glycerine,triethanolamine(in formula dosages)were selected as variable factors,the stability of the preparation was taken as the index for investigation and table L 9 (3 4 )was used to conduct the orthogonal experiment.RESULTS:The optimum base material composition and technology were the following,ciprofloxacin0.3%,carbomer-9401%,glycerine7.5%,triethanolamine2%.CONCLUSION:The compound ciprofloxacin gel prepared based on the optimized technology is in conformity with the specification stated in Chinese Pharmacopoeia(2000).
