Optimize Preparation Technique of Levofloxacin Lactate and Glucose Injection by Orthogonal Test
- VernacularTitle:正交试验优选乳酸左氧氟沙星葡萄糖注射液的制备工艺
- Author:
Guangqiu ZHANG
;
Meixiang ZHANG
- Publication Type:Journal Article
- Keywords:
Levofloxacin lactate and glucose injection;
Preparation technique;
Orthogonal test
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the preparation technique of levofoxacin lactate and glucose injection.METHODS:Orthogonal test was applied in which orthogonal table L 16 (4 5 )was chosen to perform the experiment.The effects of4factors,i.e.the pH value,amount of activated carbon added,temperature of heating and time of heating on the content of levofloxacin lactate was investigated.RESULTS:The optimum preparation technical conditions were turned out to be the following:the pH value was4.2～4.8,the amount of activated carbon was0.1%,the heating temperature was50℃with10min of heating time.CONCLUSION:The quality of the finished products from this preparation technique was in line with quality requirement.
