Efficacy and Safety of TacroUmus Ointment for the Treatment of Atopic Dermatitis in Chinese Children
- VernacularTitle:他克莫司软膏治疗儿童特应性皮炎疗效和安全性研究
- Author:
Lingling LIU
;
Xia DOU
;
Zhiqimg XIE
;
Di WANG
;
Zhizhong ZHENG
;
Minghui WEI
;
Bie YU
;
Baoxi WANG
;
Donglai MA
;
Lin LIN
;
Juanqin GONG
;
Fanqin ZENG
;
Qing GUO
;
Xuejun ZHU
- Publication Type:Journal Article
- Keywords:
Dermatitis,atopic;
Children;
Taerolimus;
Randomized controlled trials
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of 0.03% tacrolimus ointment for the treatment of atopic dermatitis (AD) in Chinese children. Methods A total of 139 children, 2 to17 years of age, with moderate to severe AD from 5 study centres were enrolled in this multicentre, randomized, double-blind, vehicle-controlled, parallel group study. Treatment with 0.03% tacrolimus ointment or vehicle was applied twice daily to the affected areas for 3 weeks. Visits were scheduled on day 1 (base line, before treatment) and 1, 2, 3 weeks after the treatment. The main therapeutic parameter was the efficacy rate at the end of the treatment. Results The efficacy rates were 84.6% and 29.0% for tacrolimus group and vehicle group, respectively (P
