Detection of Serum Anti-tyrosinase Antibodies and sICAM-1 in Vitiligo Patients
- VernacularTitle:白癜风患者血清中抗酪氨酸酶抗体及可溶性细胞间黏附分子1的检测
- Author:
Weisong HONG
;
Xiaodong WEI
;
Weiheng ZHOU
;
Aie XU
- Publication Type:Journal Article
- Keywords:
Vitiligo;
Anti-tyrosinase antibody;
Anti-melanocyte antibody;
Inlercellular adhesion molecule-1
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the activity of vitiligo and the serum levels of IgG and IgM anti-tyrosinase antibodies and sICAM-1. Methods Anli-tyrosinase, anti-melanocyte antibodies and sICAM-1 were detected by enzyme-linked immunosorbent assay. Results The average titres of IgG and IgM antibodies in the sera of patients with vitiligo were 0.316 and 0.238 respectively, which were significantly higher than those of the healthy control (both P 0.05) in the serum level of sICAM-1 between the healthy control and patients with stable vitiligo or localized vitiligo. Conclusions Both the serum levels of IgG and IgM anti-tyrosinase antibodies and sICAM-1 have a stong correlation with the activity and severity of vitiligo.
