Imbalance of Tc Cells in the Pathogenesis of Chronic Actinic Dermatitis
- VernacularTitle:Tcl/Tc2失衡和慢性光线性皮炎发病的相关性研究
- Author:
Hao CHEN
;
Danqi DENG
;
Xiaohong ZHOU
;
Yingjun FAN
;
Hongying YANG
- Publication Type:Journal Article
- Keywords:
Photosensitivity disorders;
T lymphocytes,helper-inducer;
T lymphocytes,eytotoxic;
Interleukins;
Interferon typeⅡ
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of imbalance of Tc1 and Tc2 cells with chronic actinic dermatitis (CAD). Methods Immunohistochemistry (S-P method) was used to test the subgroups of infiltrating cells and the expression of receptors of interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-12 (IL-12) and interferon-? (IFN-?) in these cells of the eruptions from 28 patients with CAD and 7 normal controls. The serum levels of IL-4, IL-10, IL-12 and IFN-? from 33 patients with CAD and 32 normal controls were tested by ELISA. Results The major infiltrating cells in the eruptions of patients with CAD were T cells, which were significantly more than B cells (P
