Cell Apoptosis and mRNA Expression of c-fos and BNIPl in Cutaneous Squamous and Basal Cell Carcinomas
- VernacularTitle:皮肤鳞状细胞癌和基底细胞癌中细胞凋亡及C-fos、BNIP1表达
- Author:
Jianqiang SHI
;
Rongyi CHEN
;
Yiming FAN
;
Zhihua WU
- Publication Type:Journal Article
- Keywords:
Carcinoma,squamous cell;
Carcinoma,basal cell;
Apoptosis;
Proto-oncogene proteins cfos;
BNIPl
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between cell apoptosis and mRNA expression of c-fos and BNIPl in cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Methods Cell apoptosis and mRNA expression of c-fos and BNIP1 in 48 SCCs and 41 BCCs were determined by TUNEL and in situ hybridization, respectively. Results Apoptosis index (AI) and c-fos mRNA expression in SCCs were higher than those in BCCs (P 0.05). AI was significantly higher in well-differentiated SCCs than in poorly differentiated SCCs (P
