Expression of Nerve Growth Factor Receptors: P75 Neurotrophin Receptor and Tyrosine Kinase A in Lesions of Psoriasis Vulgaris
- VernacularTitle:寻常性银屑病皮损中神经生长因子受体P75~(NTR)和TrkA的表达
- Author:
Ping YE
;
Rongguo HE
;
Zhihua WU
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Receptor,nerve growth factor
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of nerve growth factor receptors, P75 neurotrophin receptor (P75~(NTR)) and tyrosine kinase A (TrkA), and to explore their role in the pathogenesis of psoriasis vulgaris. Methods In situ hydridization and immunohistochemical technique were used respectively to detect the expression of P75~(NTH) and TrkA mRNA and proteins in lesional and non-lesional skins of 38 patients with psoriasis vulgaris (21 cases in progressive stage, 17 cases in static stage), and in normal skins of 10 healthy controls. Results In the case of expression of P75~(NTR) and TrkA mRNA and proteins, patients had significantly higher level than the normal control (P
