The Effects of Keratinocyte Growth Factor and Its Receptors Antisense Oligonucleotide on Prolifera- tion of HaCat Cells
- VernacularTitle:角质形成细胞生长因子及其受体反义寡核苷酸对HaCaT细胞的影响
- Author:
Erxun KANG
;
Jiarun ZHENG
;
Xinyu LI
;
Jiwei GAO
;
Lanfang XU
;
Meiyu TANG
- Publication Type:Journal Article
- Keywords:
KGF;
Cell cycle;
Apoptosis;
Oligonueleotide,antisense
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of keratinocyte growth factor (KGF) and KGF receptor (KGFR) antisense oligonucleotide (ASODN) on cell cycle and apoptosis of HaCat cells. Methods HaCaT cell, an immortalized keratinocyte cell strain, was cultured in vitro. Flow cytometry was used to measure the cell cycle and apoptosis mediated by KGF and ASODN. Results The rates of S phase and apoptosis in the group treated with KGF increased significantly than those in the control group (both P
