Effects of Chlamydia pneumoniae infection and hyperlipidemia on the expression of NF-?B and AP-1 in myocardium
- VernacularTitle:肺炎衣原体感染和高脂血症对心肌细胞NF-kappa B和AP-1的影响
- Author:
Bingsheng HUANG
;
Yugang DONG
;
Yongqiang LI
- Publication Type:Journal Article
- Keywords:
Chlamydia, pneumoniae;
Hyperlipidemia;
Myocardium;
NF-kappa B;
Transcription factor AP-1
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of Chlamydia pneumoniae infection and hyperlipidemia on the expression of NF-?B and AP-1 in the myocardium. METHODS: The indirect immunofluorescence method was used to examine wild C57BL/6J mice infected with Chlamydia pneumoniae and fed with an atherogenic diet. The expression of the subunit of NF-?B, P50, and c-Fos in the murine myocardium was observed. RESULTS: Chlamydia pneumoniae infection and hyperlipidemia induced the activation of NF-?B and AP-1 in murine myocardium. P50 and c-Fos were not detected in the controls, but there were different levels of positive expression in the experiments (P
