Activity of delayed rectifier potassium channel in alveolar macrophages from COPD rats
- VernacularTitle:慢性阻塞性肺疾病大鼠肺泡巨噬细胞延迟整流钾通道的活性研究
- Author:
Xiansheng LIU
;
Yongjian XU
;
Danlei YANG
;
Weining XIONG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease, chronic obstructive;
Membrane potentials;
Potassium channels;
Macrophages
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the change of delayed rectifier potassium channel (K_V) activity in alveolar macrophages (AM) in chronic obstructive pulmonary disease (COPD) rats. METHODS: COPD model was established by exposure of the animals to cigarette smoke. With whole-cell voltage- or current-clamp techniques, K_V activity, membrane capacitance and resting membrane potential (Em) in AM from COPD model and control rats were compared. RESULTS: (1) Significant increases in total mononuclear cells and AM in bronchoal aveolar lavage fluid (BALF) were found in COPD group compared with in control group. (2) The AM K_V current altitude in COPD group [(520.5?38.7)pA, (+50) mV, n=30] was significantly lower than that in control group [(713.6?44.4)pA, (+50) mV, n=30, P0.05), but had more positive Em (P
