Inflammation and coagulation activation are associated with gallstone formation in golden hamsters
- VernacularTitle:炎症和凝血活化亢进在仓鼠胆囊胆固醇结石形成中作用的实验研究
- Author:
Zhiqiang CHU
;
Chengzhong YOU
;
Yonglin QIN
;
Weidong CHEN
;
Huixia LU
;
Tianquan HAN
;
Shengdao ZHANG
;
Wenhao TANG
- Publication Type:Journal Article
- Keywords:
Hamsters;
Inflammation;
Cholelithiasis;
Blood coagulation factors;
Fibrinolysis;
Aspirin
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To elucidate the relationship of inflammation, coagulation and cholesterol gallstone formation. METHODS: Hamsters were divided into four groups: control group (feeding normal diet), lithogenic diet (LD) 2 weeks group, LD 6 weeks group and LD+aspirin 6 weeks group. Gallstone incidence, antithrombin antigen (AT-Ⅲ:Ag), antithrombin activity (AT-Ⅲ:Ac), thrombin (F-Ⅱa:Ac), plasminogen activator inhibitor activity (PAI:Ac), plasmin activity (Plm:Ac), D-dimer:Ag and C-reactive protein (CRP) in gallbladder bile were observed as read-out parameters. RESULTS: The incidence of gallstones in control group, LD 2 weeks group, LD 6 weeks group and LD+aspirin group were 0%, 20%, 73% and 25%, respectively. AT-Ⅲ:Ag, F-Ⅱa:Ac, D-dimer and CRP in LD 2 weeks group and LD 6 weeks group were significantly higher than those in the control group (P
