Protective effects of physcion against cerebral injury induced by ischemiareperfusion in rats
- VernacularTitle:大黄素甲醚对大鼠脑缺血再灌注损伤的拮抗作用
- Author:
Ping ZHANG
;
Likai SU
;
Huimin LI
;
Yongchen ZHAO
;
Zhangqun YANG
;
Xiuyan CUI
- Publication Type:Journal Article
- Keywords:
Physcion;
Brain ischemia;
Reperfusion injury;
Interleukin-1;
Intercellular adhesion molecule-1;
Caspase 3
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of physcion (P) on the level of IL-1? and expression of ICAM-1 and caspase-3 during cerebral ischemia-reperfusion injury. METHODS: The 91 healthy adult SD rats were selected, and were randomly divided into normal group, sham-operated group, cerebral ischemia-reperfusion group (model), low-dose physcion (PLD) and high-dose physcion (PHD) treatment group. The level of IL-1? was detected by radioimmunoassay. The expression of ICAM-1 and caspase-3 was detected by immunohistochemistry. The changes of tissue pathology were also investigated. RESULTS: The level of IL-1? reached the peak at 6 h after ischemia-reperfusion (IR). The protein expression of ICAM-1 and caspase-3 reached the peak at 24 h after IR. The level of IL-1? and the protein expression of ICAM-1 and caspase-3 in PHD group decreased obviously compared with those in model group (P
