Effect of phosphodiesterase inhibitor IBMX on cGMP production in gerbil hippocampus
- VernacularTitle:磷酸二酯酶抑制剂IBMX对海马区cGMP合成的影响
- Author:
Jingzhong NIU
;
Jingjun ZHANG
- Publication Type:Journal Article
- Keywords:
Cyclic GMP;
Brain ischemia;
Hippocampus;
Phosphodiesterase inhibitors
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of IBMX on cGMP production in gerbil hippocampus after recirculation following ischemia. METHODS: Bilateral occlusion of common carotid arteries and immunofluorescent staining methods in gerbil hippocampal tissue slice were used. RESULTS: Recirculation following ischemia caused a rise in hippocampus cGMP concentration. IBMX increased cGMP production. cGMP positive cells mainly distributed in rediatum layer and molecular layer in the CA_1 subfield. CONCLUSION: IBMX increased cGMP production in gerbil hippocampus after recirculation following ischemia.
