Preparation and Quality Control of Compound Ofloxacin Gel
- VernacularTitle:复方氧氟沙星凝胶的制备及质量控制
- Author:
Hongtu YANG
;
Linli ZONG
;
Qiying FENG
;
Cui CHANG
;
Chun DONG
- Publication Type:Journal Article
- Keywords:
Ofloxacin;
Dexamethasone sodium phosphate;
Gel;
Quality control
- From:
China Pharmacy
2005;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare compound ofloxacin gel and to establish its quality control method.METHODS:Ofloxacin was used as principal agent to be mixed with dexamethasone sodium phosphate,carbomer 940 was taken as base material,the content of ofloxacin and dexamethasone were determined by HPLC method.RESULTS:The linear detection concentration ranges of ofloxacin and dexamethasone were 20～300?g/ml and 5～50?g/ml,respectively,the average recovery rates of which were (99.8?0.5)%(RSD=0.84%)and (100.6?0.8)%(RSD=0.87%),respectively.CONCLUSION:The preparation is stable in quality,the prepare technique is simple and the quality control is reliable.
