Preparation and Quality Evaluation of Ambroxol Hydrochloride Orally Disintegrating Tablets
- VernacularTitle:盐酸氨溴索口腔崩解片的制备及质量评价
- Author:
Wei XI
;
Shuyin ZHANG
;
Changyou XIONG
- Publication Type:Journal Article
- Keywords:
Ambroxol hydrochloride;
Orally disintegrating tablets;
Preparation;
Quality evaluation
- From:
China Pharmacy
2005;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare ambroxol hydrochloride orally disintegrating tablets and to evaluate its quality.METHODS:Mannitol was used as main adjuvant to prepare ambroxol hydrochloride orally disintegrating tablet,the UV spec-trometry was adopted to determine ambroxol content,the disintegration time,taste and dissolution rate were evaluated.RESULTS:The optimal formulation was composed of MCC 50g,mannitol 20g,L-HPC 10g,and NaHCO3 2g;The detected concentration of ambroxol was linear in the range of 0.005～0.030mg/ml(r=0.9 999),the average recovery was 100.50%and RSD=0.71;The prepared tablets disintegrated completely within 30s.CONCLUSION:The orally disintegrating tablets is quick to disintegrate and is as effective as market tablets.
