Effect of uroacitides on apoptosis of breast cancer cells
- VernacularTitle:尿多酸肽对乳腺癌细胞凋亡的影响
- Author:
Wei ZHENG
;
Lin MA
;
Lin CHEN
;
Rong LI
;
Yanyong JIANG
- Publication Type:Journal Article
- Keywords:
Breast Neoplasms;
Apoptosis;
Uroacitides
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of CDA-II on apoptosis of breast cancer cells. Methods The effects of CDA-II on growth curve, cell apoptosis and morphology of breast carcinoma cell lines MCF-7 and MDA-MB-231 were observed by in vitro cultures, and compared with the classical cell differentiation inducer ATRA. MCF-7 and MDA-MB-231 cell lines have their different biologic characteristics. Results CDA-II can reduce growth and proliferation ability and induce cell apoptosis of breast cancer cell lines( MCF-7 and MDA-MB-231). Conclusions CDA-II has remarkable effect of anti-cell-proliferation and induction of (apoptosis) on breast cancer cells MCF-7 and MDA-MB-231 . Our results provide experimental bases for the treatment of breast carcinoma with CDA-II.
